Dir: Coralie Fargeat
Cast: Margaret Qualley, Dennis Quaid, Demi Moore
141 mins

Please Note: The Substance contains flickering or flashing lights that may affect those with photosensitive epilepsy.

Demi Moore gives a career-best performance as Elisabeth Sparkle, a former A-lister past her prime and suddenly fired from her fitness TV show by repellent studio head Harvey (Dennis Quaid).

She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn – temporarily – as the gorgeous, twentysomething Sue (Margaret Qualley).

The only rule? Time needs to be split: exactly one week in one body, then one week in the other. No exceptions. A perfect balance. What could go wrong?

Deliriously entertaining and ruthlessly satirical, Coralie Fargeat’s Cannes sensation turns toxic beauty culture inside out with a be-careful-what-you-wish-for fable for the ages. Explosive, provocative and twisted, THE SUBSTANCE marks the arrival of a thrillingly visionary filmmaker.

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